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Category 1 OTC medicines

HICEE B MATE 2
ハイシーBメイト2

CHARACTERISTICS

  • Two main active ingredients to improve skin roughness and acne:
  • Vitamins B2 and B6, which assist in the metabolism of lipids and proteins to help the regrowth of skin cells from inside the body
  • Four active ingredients to help improve skin roughness and acne:
    1. Vitamin C, which is essential for collagen production
    2. L-cysteine, which assists in the metabolism of skin (turnover)
    3. Biotin, which assists in the metabolism of lipids
    4. Nicotinamide, the deficiency of which results in the skin being more prone to roughness
  • This medicine is supplied as an easy-to-take, white tablet to be taken once daily, two tablets per dose (15 years or over).
  • This medicine is sugarless.

INDICATIONS

  1. Relief of the following symptoms:
    • Skin roughness, acne
    • Eczema, dermatitis, rash, sores
    • Stomatitis, angular stomatitis, cheilitis, glossitis
  2. Supply of vitamins B2 and B6 in the following cases:
    Physical fatigue, during pregnancy or lactation, and loss of strength during or after illness.

If the symptoms described in points 1 do not improve after using this medicine for about one month, consult your physician or pharmacist.

DOSAGE AND DIRECTIONS

Take the following amount of medicine without chewing, with cold or lukewarm water.

Age One dose Daily dose
15 years or over 2 tablets Once
7 - 14 years 1 tablet
Under 7 years Do not take.

Precautions regarding dosage and directions

  1. Children are permitted to take this medicine only under the direction and supervision of a parent or other responsible adult.
  2. Please follow the recommended dosage and directions.
  3. The medicine is to be taken once daily at any time of the day.

INGREDIENTS

In two 2 tablets (daily dosage for persons aged 15 years or over)

Ingredients Contents
Riboflavin (vitamin B2) 30mg
Pyridoxine hydrochloride (vitamin B6) 100mg
Ascorbic acid (vitamin C) 150mg
L-cysteine 60mg
Nicotinamide 60mg
Biotin 75μg

Inactive ingredients:

Hydroxypropylcellulose, magnesium stearate, cellulose, hypromellose, erythritol, macrogol, titanium dioxide, acacia, talc

Precautions regarding ingredients

Although urine may turn yellow after taking this medicine, do not worry because this is caused by riboflavin in this medicine.

About the “regrowth of skin cells”

Our bodies are made up of about 60 trillion cells and our skin is also a collection of cells. In the deeper part of the skin, new skin cells are constantly regenerated. The regenerated skin cells are pushed gradually towards the outermost surface of the skin and then finally peel off. This is how skin cells are constantly renewed.
The cells consist mainly of proteins, lipids, and water. A sufficient supply of nutrients and vitamins, which are the sources of proteins and lipids, is required for the skin cells to regenerate.
Vitamin B2 is involved in the metabolism of lipids and vitamin B6 is involved in the metabolism of proteins; both vitamins are important for the renewal of cells.

PRECAUTIONS FOR USE

Who should seek consultation

  1. Stop taking this medicine immediately and consult a physician, pharmacist, or registered salesperson* if the following symptoms appear after taking this medicine because they might be side effects of the medicine. Take this leaflet with you.
    Affected area Symptoms
    Skin Rashes
    Digestive organs Stomach discomfort, nausea, vomiting, abdominal pain
  2. Stop taking this medicine and consult a physician, pharmacist, or *registered salesperson if the following symptoms appears after taking this medicine and continues or worsens. Take this leaflet with you.
    Diarrhea
  3. Stop taking this medicine and consult a physician, pharmacist or registered salesperson if symptoms do not improve after taking this medicine for about one month. Take this leaflet with you.

*Registered salesperson: person who has the license to sell OTC medicines except Category 1.

PRECAUTIONS FOR STORAGE AND HANDLING

Product in a bottle or unit dose packaging

  1. Keep out of the reach of children.
  2. Do not take this medicine after the expiration date.

Product in a bottle

  1. Keep the bottle tightly closed and put it in the box. Store the box in a dry, cool place away from direct sunlight.
  2. To prevent improper use and loss of quality, do not transfer the medicine to another container.
  3. Once the bottle is opened, throw away the filler in the bottle. (Putting the filler back into the bottle may change the quality by absorbing moisture. The filler in the bottle protects the tablets from breakage during transportation.)
  4. Be sure to close the cap tightly after each use. (Failure to tightly close the bottle may result in loss of the quality of the medicine due to moisture.)
  5. Fill in the date when the bottle was opened in the column provided on the box and bottle.
  6. Once the bottle is opened, take this medicine within about 6 months to maintain quality.

Product in unit dose packaging

  1. Store in a dry, cool place away from direct sunlight.
  2. When taken in divided doses, fold over the opened edge of the pouch and store it. The medicine should be taken within four 4 days.